Introduction: In recent years, the incidence of COLORECTAL cancer has declined dramatically. Screening programs, based on endoscopic resection of polypoid precancerous lesions, have fulfilled a fundamental role in this improvement. Methods: The present work took the form of a retrospective observational study of a set of patients who had undergone endoscopic resection of colonic polypoid lesions between January 2007 and December 2012. We analyzed the rate of polyps per colonoscopy, number of patients, follow-up time, and relationship with later cancer appearance. Results: The study population was composed of 841 patients, including 357 women (42. 4%) and 484 men (57. 65%), with a sum of 7007 COLORECTAL polyps and a mean follow-up of 66±, 21. 84 months. During the followup period, 12 patients were diagnosed with COLORECTAL cancer,these patients were not significantly different relative to the remaining patients in terms of rate of polyps per colonoscopy, number of advanced adenomas (Z=0. 11, P=0. 91), and total adenomatous polyps (Z=1. 84, P=0. 07). Nevertheless, we could see that patients without COLORECTAL cancer had a lower rate of advanced adenoma polyps per colonoscopy (Z=4. 61, P<0. 001) and a lower raw number of polyps (Z=7. 09, P<0. 001). Conclusion: When comparing rates by number of patients, number of colonoscopic explorations, and follow-up time, the advanced adenoma rate was found to be higher in patients who later developed COLORECTAL CARCINOMA. We conclude that perhaps the recommended follow-up intervals should be shortened slightly, paying special attention to follow-up in those patients who have AAs in the initial colonoscopy.

Background: The p53 gene mutation is closely related to carcinogenesis in most malignant diseases. The main function of wild p53 protein is to maintain the integrity of genes by detecting mutations and preventing the division of cells with damaged DNA. The mutated form of p53 protein is overexpressed due to an extended half-life and can be easily detected by immunohistochemistry. Objective: To estimate the frequency of p53 protein overexpression in COLORECTAL CARCINOMA and its correlation with some clinicopathologic variables.Methods: One hundred paraffin-preserved COLORECTAL CARCINOMA samples were collected randomly from patients undergoing tumor resection from April 1995 through April 2001 in Omid Hospital, affiliated to Mashhad University of Medical Sciences, Mashhad, Iran. The overexpression of p53 protein was studied using a monoclonal antibody (clone DO-7; Dako). The number of cells stained were classified semiquantitatively as (–): <5% positive cells, (+): 5 – 25% positive cells, (++): 25 – 75% positive cells, and (+++): >75% positive cells. Clinicopathologic data including gender, age, tumor location, histologic type, and stage (Astler-Coller) were collected from the files maintained at the Department of Pathology. The correlation between p53 protein overexpression and each variable was evaluated using Chi-square analysis.Results: p53 staining was positive in 59 of 100 specimens. Out of these 100 specimens, 16 were weekly (+), 16 moderately (++), and 27 intensely (+++) positive for p53 protein overexpression. There was no significant correlation between p53 staining and gender (P=0.34), age (< 40 vs. ≥ 40 yr; P=0.74), site of tumor (right vs. left colon and rectum; P=0.26), pathologic type (mucinous vs. nonmucinous; P=0.63), and stage of the disease (P=0.12).Conclusion: Considering the p53 protein overexpression in a relatively high percentage of patients, it seems that p53 mutation plays an important role in development of COLORECTAL CARCINOMA. There was no significant association between p53 protein expression and some common clinicopathologic variables such as age, gender, site of tumor, pathologic type, and stage of the disease.

Zinc has an important role in skin health and its deficiency reduces immunity to evaluate levels of zinc in squamous cell CARCINOMA (SCC) and basal cell CARCINOMA (BCC) of skin, we studied 44 BCC and 38 SCC cases together with 33 controls. Blood samples were taken and after separation of serum, levels of zinc, albumin and total protein were measured by atomic absorption albumin kit and reflectometer consecutively. Serum globulin levels were estimated by subtracting albumin from total protein levels. Zinc levels were significantly lower in cancer cases than control (P<0.001). Mean serum albumin of BCC cases was significantly more than controls (P<0.01), but in BCC cases was not significantly different. Significant correlations were seen between levels of serum zinc and albumin of SCC (r=0.507, P<0.01) and BCC(r=0.43, P<0.01) patients and controls(r=0.35,P<0.01). Mean globulin levels in cancer cases were significantly lower than control group (P<0.01).We concluded that serum zinc and globulin levels decrease in BCC and SCC of skin.